Scanning electron micrographs of an embryo at Carnegie stage 10 (approximately week 4)
Because life is too short to live without science.
Hi, I'm Steph! And I am currently studying HND Applied Biological Science (2nd year university level to those not familiar with Scottish qualifications).and this is a blog dedicated to my learning about reproductive and developmental biology. As I learn, I shall post, feel free to correct and educate, and I am open to suggestions on possible topics. Happy reading!
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This confocal micrograph shows stage V–VI oocytes (800–1000 micron diameter) of an African clawed frog (Xenopus laevis), a model organism used in cell and developmental biology research. Each oocyte is surrounded by thousands of follicle cells, shown in the image by staining DNA blue. Blood vessels, which provide oxygen to the oocyte and follicle cells, are shown in red. The ovary of each adult female Xenopus laevis contains up to 20 000 oocytes. Mature Xenopus laevis oocytes are approximately 1.2 mm in diameter, much larger than the eggs of many other species. (Photo by Vincent Pasque, University of Cambridge/Wellcome Images)
(via Up Close: 2012 Wellcome Image Awards)
Top: Uterine lining at 5 1/2 months, displaying thin maternal separation from fetus, and high level of placental implantation
Center: Relation of placenta to uterus at 5 weeks and 8.5 months
Bottom: Major arteries and veins of the placentaDid you know that the placenta is a temporary organ that’s actually created by the fetus, and not the woman?
The human female is a curious creature; like our close great ape cousins, but unlike almost all other mammals, they build up a thick barrier in the uterine wall, to protect against any potential embryo that might implant itself. When there’s no embryo implantation, the thickened wall is shed, in the process known as menstruation.
The thing is, most mammals don’t menstruate. They go into heat, and occasionally shed uterine lining (if the uterus is scratched, or an egg tries to implant but fails, for example), but there’s no regular cycle of bloody discharge relating to breeding. This is because other mammals go through triggered decidualization (developing a uterine lining only when a fertilized egg begins to implant itself), while the great apes (and a couple other convergently evolved families, including bats) experience spontaneous decidualization, where they develop a thick uterine lining during every ovulation, before an egg can even attempt to implant itself.
Why the different linings? Well, it turns out that there are three types of mammal placentas (remember, placentas are developed by the embryo/fetus, not the mother):
- Epitheliochordal, which is completely superficial, and does not connect in any significant way to the mother’s body. The endometrial epithelium, connective tissue, and uterine epithelium are all preserved and undisturbed in the mother. The fetus is separated from the mother by three layers of tissue. Nutrients and waste are delivered and eliminated through diffusion, rather than direct connection. This group includes equids, swine, and ruminants.
- Endotheliochordal, which is slightly more invasive to the mother, only preserves the uterine epithelium. Nutrients and waste are not exchanged through direct connection to the mother, but the placenta only leaves one layer of tissue between it and the mother. This group includes cats and dogs.
- Hemochorial is the most invasive form of placenta in the animal kingdom. The embryo directly hooks itself up to the host (mother’s) blood flow, and leaves no tissue layers between the female and the placenta. This allows much more efficient nutrient transfer to the embryo or fetus, but is also potentially the most harmful to the female since the embryo attaches itself so securely to the uterine wall. The female must develop preemptive measures (a thickened uterine lining) to protect herself from a life-form that is literally driven to take all of the nutrients it needs to develop, and which has adapted to connect itself directly to the host. This group includes elephant shrews, most bats, and most primates.
Interested in more about the science behind reproduction and how amazingly efficient the human embryo is at sucking its host clean, just to obtain its needed resources for development?
PZ Meyers at Pharyngula has an understandable explanation of the article I referenced for this post.
There is also a great site by R. Bowen about the pathophysiology of the reproductive system.
An American Text-Book of Obstetrics for Practitioners and Students. Edited by Richard C. Norris, 1895.
(via fyeahmedlab)
Embryology of the Diaphragm
(Source: cranialintelligence.files.wordpress.com)
Bat Embryos
The first image are embryos of the species Molossus rufus, the black mastiff bat. These images formed part of an embryonic staging system for this species. — By Dorit Hockman
The second image shows a bat embryo developing from 18 weeks to 24
(via many-splendored-rat)
Epithelial cells line surfaces and cavities throughout the body, forming skin, glands, and tracts. This mouse embryo has been genetically engineered to allow for the visualization of epithelial cells, showing the pattern of whisker placement on the face.
Image by Evan Heller, Rockefeller University.
A chicken embryo inside of an egg. By the 72 hour stage the heart is well developed and the somites, optic vesicle, tail and leg buds are visible. Fractal networks of blood vessels bring energy from the yolk and exchange carbon dioxide with oxygen in the allantois.
Embryonic Rat Thoracic Aorta Medial Layer Myoblast Cells (A-10 Line)
A culture of adherent A-10 rat thoracic aorta cells was fluorescently triple-labeled with MitoTracker Red CMXRos, Alexa Fluor 350 conjugated to phalloidin, and SYTOX Green, targeting the mitochondria, filamentous actin network, and nuclei, respectively. In this image, the bright red mitochondrial network is superimposed on a deep blue actin cytoskeletal framework centered around the green nuclei.
(via fyeahmedlab)
Evolutionary Perspectives on Pregnancy by John C. Avise
“Covering both the internal and external incubation of offspring, this book provides a biology-rich survey of the natural history, ecology, genetics, and evolution of pregnancy-like phenomena. From mammals and other live-bearing organisms to viviparous reptiles, male-pregnant fishes, larval-brooding worms, crabs, sea cucumbers, and corals, the world’s various species display pregnancy and other forms of parental devotion in surprisingly multifaceted ways. An adult female (or male) can incubate its offspring in a womb, stomach, mouth, vocal sac, gill chamber, epithelial pouch, backpack, leg pocket, nest, or an encasing of embryos, and by studying these diverse examples from a comparative vantage point, the ecological and evolutionary-genetic outcomes of different reproductive models become fascinatingly clear.
John C. Avise discusses each mode of pregnancy and the decipherable genetic signatures it has left on the reproductive structures, physiologies, and innate sexual behaviors of extant species. By considering the many biological aspects of gestation from different evolutionary angles, Avise offers captivating new insights into the significance of “heavy” parental investment in progeny.”
Quadruple helix' DNA discovered in human cells
In 1953, Cambridge researchers Watson and Crick published a paper describing the interweaving ‘double helix’ DNA structure - the chemical code for all life. Now, in the year of that scientific landmark’s 60th Anniversary, Cambridge researchers have published a paper proving that four-stranded ‘quadruple helix’ DNA structures - known as G-quadruplexes - also exist within the human genome. They form in regions of DNA that are rich in the building block guanine, usually abbreviated to ‘G’.
The findings mark the culmination of over 10 years investigation by scientists to show these complex structures in vivo - in living human cells - working from the hypothetical, through computational modelling to synthetic lab experiments and finally the identification in human cancer cells using fluorescent biomarkers.
Read more at: http://phys.org/news/2013-01-quadruple-helix-dna-human-cells.html#jCp
(Source: ohyeahdevelopmentalbiology)